November 20, 2024
 
VIA EDGAR
 
U.S. Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, DC 20549

Attention:

Tamika N. Sheppard
     
 Re:
 
Gyre Therapeutics, Inc.
 
 
Registration Statement on Form S-3 (File No. 333-283237)

Ladies and Gentlemen:
 
Gyre Therapeutics, Inc. hereby respectfully requests that, pursuant to Rules 460 and 461 promulgated under the Securities Act of 1933, as amended, the effectiveness of the above-referenced Registration Statement on Form S‑3 be accelerated so that it will become effective on November 22, 2024, at 4:15 p.m., Eastern Time, or as soon as practicable thereafter, unless we or our outside counsel, Gibson, Dunn & Crutcher LLP, request by telephone that such Registration Statement be declared effective at some other time.
 
We request that we be notified of such effectiveness by a telephone call to Branden C. Berns of Gibson, Dunn & Crutcher at (415) 393-4631.
       
 
Sincerely,
   
 
GYRE THERAPEUTICS, INC.
     
 
By:
 
/s/ Han Ying
   
 
Han Ying, Ph.D.
   
 
Chief Executive Officer
 
cc:
Ruoyu Chen, Gyre Therapeutics, Inc.
Ryan A. Murr, Gibson, Dunn & Crutcher LLP
Branden C. Berns, Gibson, Dunn & Crutcher LLP